# Input alignment A stat5a_ENSPPYP00000009439 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QKTYDRCPMELVRCIRHILYNEQRLVREAN---NCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNLYPQNPDHVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS stat5a_ENSECAP00000011069 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDQAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QNTYDRCPMDLVRCIRHILYNEQRLVQEAN---NGTSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSSHLEDYNSMAVSWAQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLI----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVSASADSAGGSATYMDQAPSPAVCPQAHYNMYPQNPDPVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDPRLSPPAGLFTSARGSLS stat5a_ENSMMUP00000014026 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QNTYDRCPMELVRCIRHILYNEQRLVREAN---NCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALRQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEKMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGSGSATYMDQAPSPAVCPQAHYNMYPQNPDPVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS stat5a_ENSRNOP00000026662 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QNTYDRCPMELVRCIRHILYNEQRLVREAN---NCSSPAGVLVDAMSQKHLQINQTFEELRLITQDTESELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLI----------YVFPDRPKDEVFAKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASAD-AGANATYMDQAPSPVVCPQAHYNMYPPNPDPVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDPRLSPPAGLFTSARSSLS stat5a_ENSCPOP00000010976 MASWIRAQQLQGDALHQMQALYGQHFPIEVRHYLAQWIESQA-WDAIDVDSPQDHAQAAQLLEGLVQELQRKAEHQVGEDGFLLKIKLGHYAMQL--QSTYDRCPLELVRCIRHILYNEQRLVREAT---NGSSPASSLPDTLSQKHLQINQTFEELRLVTQDMENELKKLQQAQEYFIIQYQESLRVQAQFTQLAQVSPQERLSRESALQQKQATLEAWLQREAQTLQRYRVELAEKHQKTLQLLRKQQTVILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAELIWQNRQQIRRAEHLCQQLPIPG-PVEEMLADVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKALLKSE-STHNECSGEILNNCCVMEYQQASGTLSAHFRNMSLKRIKRAD----RRGTESVTEEKFAILFQSQFSVSGHELVFQVKILSLPVVVIVHGSQDHNATATVLWDNAFAELGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSARGLTKENLVFLAQKLFSSSSSHLEDYSSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKRHHKSHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGVTIAW--KFDSPDRNLWNLKPFTTRDFSIRSLADRLSDLSYLA----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFATASAD-SGASATYVDQALSPAVCPQAPYNLYPQNPDPVLDQEAEFDL-DETMDVARHVEELLRRPAGGLDSRLSPPEGLFALAPGSLS stat5a_ENSP00000341208 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QKTYDRCPLELVRCIRHILYNEQRLVREAN---NCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS stat5a_ENSTTRP00000006772 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRPQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QNTYDHCPMELVRCIRHILYNEQRLVREAN---NGSSSSGILVDAMSQKHLQINQTLEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLNPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDMLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSGSSHLEDYNGMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVSASADSAGSSATYMDQAPSPAVCPQAHYNMYPQNPDPVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDPRLSPPTGLFTSARGSLS stat5a_1y1u -----------------------------------------------------------------------------------------------------------------------------------------------SQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKR-------------ESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLI----------YVFPDRPKDEVFAKYYTPV-----LAKA--------------------------------------------------------------------------------------------------------- stat5a_ENSPTRP00000015668 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QKTYDRCPMELVRCIRHILYNEQRLVREAN---NCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS stat5a_ENSCAFP00000022653 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYASQL--QNTYDGCPMELVRCIRHILYNEQRLVREAN---NGNSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFSQLAQLNPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NARNECSGEILNNCCVMEYHQATCTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSSSSHLEDYNGMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLI----------YVFPDRPKDEVFSKYYTPVFAPLLAAKAVDGYVKPQIKQVVPEFVSASTDSAGASATYMDQAPSPAVCPQAHYNMYPQNPDSVLDQDGEFDL-DETMDVARHVEELLRRPMDSLDPRLSPPAGLFTAARGSLS stat5a_ENSPCAP00000009493 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQP-WDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQL--QNTYDRCPMELVRCIRHILYNEQRLVREAN---NCSSPAGSLADAMSQKHLQINQTFEELRRVTQDTENELKKLQQTQEYFIIQYQESLRVQAQFAQLAQLNPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIAG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE-NTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRAD----RRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNSGHSHLEDYSSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKYHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLI----------YVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNVSADSAGSNATY-DPAPSPAVCAQAHYNMYPXXPDPVLDQDGEIDL-DETMDVARHVEELLRRPMDSLGPSLAPPDGFFAAARGSLP 433424244433224323322433344322422442444243443232223223113222422223234322222222423242233232320244440322034022323432343343433224232231133331303222323232222322322334222322432332432432343333333333132322122333232222243322430343233334333434232422222232223322242244224444442423444322342344323332423334223432332322232333234332322222333223432422234334244333333324222442234323244423344332233234422233333342222224432322222223232232333334244334433324324222323333422244443332244222232333433333424442424333443322343224342232222332342343233234424323334332233344432234234234423022232242111322423433422443232442432233233444234243443234443432332443342344444444343344443343222223132323334323233433334432343133222223333332334434442343234233444442223222222222223243221333311301222022222223322202312402220323232222242222222222233333333333133333133311333333 CSSCSCSCCCSSSSCSSSSSSCSSSCCSSSCSSCCSCCCSCSCCSSSSSSSSSSSSSSSSCSSSSSSSCSSSSSSSSSCSSSCSSSSSSSSS0SCCCC0SSS0SC0SSSSSCSSSCSSCSCSSSSCSSSSSSSSSSSSS0SSSSSSSSSSSSSSSSSSSSSCSSSSSSCSSSSSCSSCSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSCSSSSCS0SCSSSSSSCSSSCSCSSSCSSSSSSSSSSSSSSSCSSCCSSCCCCCCSCSSCCCSSSSCSSCCSSSSSSCSSSSCSSSCSSSSSSSSSSSSSSSSCSSSSSSSSSSSSSSSCSSCSSSSCSSCSCCSSSSSSSSCSSSCCSSSCSSSSCCCSSSCCSSSSSSSSCCSSSSSSSSSCSSSSSSCCSSSSSSSSSSSSSSSSSSSSSSCSCCSSCCSSSSCSSCSSSSSSSSSCSSSCCCCSSSSSCCSSSSSSSSSCSSSSSCSCCCSCSCSSSCCSSSSSCSSSCSCSSSSSSSSSSSCSSCSSSSSSCCSCSSSSSCSSSSSSSCCCSSSSCSSCSSCCSS0SSSSSSCSSSSSSSCSSCSSCSSCCSSSSCCSCSSSSSSSSCCCSSCSCSCCSSSCCCSCSSSSSCCSSCSSCCCCCCCCSCSSCCCCSSCSSSSSSSSSSSSSSSCSSSSSSCSSSSCCSSSCSSSSSSSSSSSSSSSSSSCCSCCCSSCSSSCSSSCCCCCSSSSSSSSSSSSSSSSSCSSSSSSSSSSS0SSSS0SSSSSSSSSSSS0SSSSC0SSS0SSSSSSSSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS # Input alignment B stat4_ENSGACP00000003526740 MSQWKQIQQLEIRLLEHVDYLYDDNFPMDIRQGLSSWIESQD-WEIAASDESM----AAVLFRDLLSQLDKVR---LQEQNFLQRHNMKIIQQQL--QVKYTTNPIAMARVISTCLREERRILSSACMQEQGPLEKSLQNSVALEKQKNMDNRVGIIRANVQLMDQAVKYIEDMQDDFDFRYK----------TLQSRESTDTRQNSEMMKQEVTRLQEMLNR----LDYKRKEILSKMDDVIKEIDDLMTSQLNPELQDWKRRQQIAAIGGPLLTGLEQLQSWFTLIAQSLFQIKRQLDKLVELVVKVTYESDPIPLQKHQMEERIKYLIYHLIKSSFVVEKQPCMPTHPQKPLIIKTGVQFTTKVRLLV--KLPEVDYQLKVKTTF-----DKDLPSGRVSRQFFILTNNTKVMDIEDYSN--GCLSVDFRHLQLKEKKYINGTKGSEGLLSVTEELHSLSFEACFTVQG--LTIDLETCSLPLVVISNVSQLPGGWASVMWYNLLTDEPRNMAFFGNPPRATWSQLSEVLSWQFSTFA--GKGLNKEQLNMLGEKLL-GQHVSCSDYQ---VSWSKFSKENIPGKPFSFWMWLDSILELIKKHLLPVWNENYIMGFVSKEMERTLLKDREPGTFLLRFSESHLGGITFTWVEHNANGGVKFNSVEPYTKNRLSALPFADIIRDYKVISDGVVPETPLKFLYPDIPKDEAFGRLYNSQ-----PSK-----VHP----YIPSTL------IPISELRTHAISTAPSRQSPEPPMTPGEFDMLSEQLC-FDI--DSMSSSYSE------------------------------ stat4_ENSTRUP00000028049739 MSQWKQIQNLEIRLLEHVDYLYDDNFPMDIRQVLASWLESQD-WDTAASDESL----SAVLFTNLLSQLDRVRAH---ELNFLQRHNMKMIQQQL--QVKYSSSPVNMAKVISTCLREERRILSSVCMQEQGPLEKSLQNSVAFERQKNMDNRVGIIRGSVQLMDQAVKYIEDMQEDFDFRYK----------TLQSRDSTD--RNADFIKQEVTRLQDMLNR----LDFKRKEILSKMDVAVKEIEDLMTSQLSPELQDWKRRQQIAAIGGPLLTGLDQLQNWFTLTAQSLFQIKRQLDKLGELVIKVTYECDPIPLQKPQLEERVKYLLYHLIKSSFVVEKQPCMPPHPQKPLIIKTGVQFTTKVRLLV--KLPEVDYQLKVKTIF-----DKNFR----SRQFFILTNNTKVMDIEDYSN--GCLSVEFRHLQLKEKKYINGTKGNEGLLSVTEELHSLSFEACFTVQG--LTIDLETSSLPLVVISNVSQLPGGWASVVWYNLLTDEPRNLAFFCNPPRATWSQLSEVLSWQFSTLA--GQGLTKEQLSTLGEKLL-GQHASCSEYH---VSWSKFAKENIPGKPFSFWMWLDSILELIRKHLLPVWNANYIMGFVSKEMERNLLKDREPGTFLLRFSESHLGGITFTWVEHKDNGEVKFNSVEPYTKNRLSALPFVDIIRDYKVISDGVVPENPLKFLYPDIPKDEAFGRLYNSQ-----RSK-VTPPVYP----YIPSTL------IPIS-VRENSSTTPASNQSPELPMTLGEFDLLREQLC-FDL-DTVSFHTLSSN----------------------------- stat4_ENSDARP00000059650669 MSQWKQVQQLDIKFLEQVDYFYDDNFPMELRQVLANWIESQD-WETASNHESM----ATVLFNNFLIQLERQCSQ---EQNFLHRHNLKRIFHQI--QVKYKANPLQMAAVICNCLREERRILSTASMQEQGPLEKSMQNSAALEKQKVLDNKVAVIRSSVQMLDQAVKYLEDMQDDFDFRYK----------TLQLRDPLE--RNSSSMKQEVTTLQEILNR----LDFKRKTA-----DVIKEIDALISSQLNPELKEWKRRQQIACIGGPVLIGLDQLQNWFTLTAQSLFQIKRQLDKLGELILKVTYESDPIPLQRPQMEEQVKYLIYHLIKSSFVVEKQPCMPTHLQKPLIIKTQVQFTTKVRLLV--KLPEVDYQLKVKTTF-----DK-------NRQFFILTNNTKVMDVEEST---GCLSVEFRHLQLKERKCPTGGKGNEGPLSVTEELHSLNFEAMLMLQG--LDIDLETCSLPLVVISNVSQLPGGWASVMWYNLLTDDPKNLAFFSNPLRASWSQLSEVLSWQFSSFA--GRGLNKEQLNMLGDKLLEGQHGSYNDCQ---VSWSKFCKEVIPGKSFSFWMWLDSILDLIKKHLLPVWIDGCIMGFVSKEMERALLKEKEPGTFLLRFSESHLGGITFTWVEQDENGDPKFISVEPYTKNRLNALPIADIIRDYKVIADGVVPENPLNFLYPDIPKDEAFGKHYNSQ-----QNKG--------------------------------------------------------------------------------------------------------- stat4_ENSP00000376134748 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQD-WEAASNNETM----ATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVL--QGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK----------TIQTMDQSD--KNSAMVNQEVLTLQEMLNS----LDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLS-NRRFVLCGTNVKAMSIEESSN--GSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--GRGLNSDQLHMLAEKL--TVQSSYSDGH---LTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQ-----PCE-VSRPTERGDKGYVPSVF------IPISTIRSDSTEPHS--PSDLLPMSPSVYAVLRENLSPTTI-ETAMKSPYSAE----------------------------- stat4_ENSMUSP00000027277748 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIETQD-WEVASNNETM----ATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVL--QGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVSAIKNSVQMTEQDTKYLEDLQDEFDYRYK----------TIQTMDQGD--KNSILVNQEVLTLQEMLNS----LDFKRKEALSKMTQIVNETDLLMNSMLLEELQDWKKRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRQQLEKLQEQSTKMTYEGDPIPAQRAHLLERATFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLS-NRRFVLCGTHVKAMSSEESSN--GSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYG--LTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYV--GRGLNSEQLNMLAEKL--TVQSNYNDGH---LTWAKFCKEHLPGKTFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDQSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQ-----PCE-VSRPTERGDKGYVPSVF------IPISTIRSDSTEPQS--PSDLLPMSPSAYAVLRENLSPTTI-ETAMNSPYSAE----------------------------- stat4_ENSMLUP00000000056748 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQD-WEAASNNETM----ATILLQNLLIQLDDQLGRVSKEKNLLLIHNLKRIRKVL--QGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQITEQDTKYLEDLQDEFDYRYK----------TIQMMDQGD--KNNALMSQEVLTLQEMLNS----LDFKRKEALGKLTQIVSETDLLMSSMLVEELQDWKRRQQVACIGGPLHSGLDQLQNCFTLLAESLFQLKRQLEKLEEQSSKVTYEGDPIPLQRPHLLERVTFLICSIFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLS-NRRFVLCGTHVKAMSIEESSN--GSLSVEFRHLQPKEMKSTAGSKGNEGCHMVTEELHSITFEAQICLYG--LTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--GRGLNSDQLNMLAEKL--TAQSSYSDGH---LTWSKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGCVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHAESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENVPENPLKYLYPDIPKDKAFGKHYSSQ-----PCE-VSRPTEKGDKGYVPSVF------IPISTIRSDSTEPQS--PSDLLPMSPSVYAVLRENLSPTTI-ETAMKSPYSAE----------------------------- stat4_ENSMODP00000014736749 MSQWNQVQQLEIKFLEQVDQFYDDTFPMEVRHLLAQWIEGQD-WEAASNNETM----ATILLQNLLLQLDEQLGRVAQEKNLLLIHNLKRIRKLL--QGKYHGNPMHIAVVISNCLREERRILAAASMPVQGPLEKSLQSSVVSERQRNVEHKVAAIKNSVQMTEQDAKYLEDLQDEFDYRYK----------TIQTIDQGD--KNSVLVKQEVMTLQDMLNT----LDFKRKEVLSKITQIISEIDTLMNTMLLEELLDWKRRQQIACIGGPLHSGLDQLQNCFTLLAESLFQVRRQLEKLDEQSTKVSYEGDPIPLQRSHLQERVNFLIYNLFRNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLI--KLPELNYQIKVKATI-----DKNVSTVS-NRRFILCGTHVKAMNMEESSN--GSLSVEFRHLQPKEMKSSAGGKGNEGPHMVTEELHSISFETQICLYG--LTIDLETNSLPVVMISNVSQLPNAWASIIWYNLSTNDSQNLVFFNNPPTAALSQLLEVLSWQFSSYV--GRGLNSDQLNMLAEKLT-ASQASYSDGQ---LSWAKFCKEHLPGKAFTFWVWLEAILDLIKKHILPLWIDGYIMGFVSKEKERVLLKDKMPGTFLLRFSESNLGGITFTWVDQSENGEVRFHSVEPYNKGRLAALPFADILRDYKVIMAENVPENPLKYLYPDIPKDKAFGKHYSSQ-----PNE-VSRPTERGDKGYVPSVF------IPISTIRSDSTEPRS--PSDLLPMSPSVYAVLREHLSPTVI-ETAMSSPYSAD----------------------------- stat4_ENSPPYP00000014556697 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQD-WEAASNNETM----ATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVL--QGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK----------TIQTMDQSD--KNSAMVNQEVLTLQEMLNS----LDFKRK---------------------------------------------------FTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLS-NRRFVLCGTNVKAMSIEESSN--GSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--GRGLNSDQLNMLAEKL--TVQSSYSDGH---LTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQ-----PCE-VSRPTERGDKGYVPSVF------IPISTIRSDSTEPHS--PSDLLPMSPSVYAVLRENLSPTTI-ETAMKSPYSAE----------------------------- stat4_ENSBTAP00000030561331 -------------------------------DLLTHFKES-S-W--------------------------------------------------------FY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNASTLS-NRRFVLCGTHVKAMSIEESSN--GSLSVEFRHLQPKEMKSSAGNKGNEGCHMVTEELHSITFETQICLYG--LTIDLETCSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSATLSQLLEVMSWQFSSYV--GRGLNSDQLNMLAEKL--TVQSSYNDGH---LTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYIMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQ-----PCE-G-------------------------------------------------------------------------------------------------------- stat4_ENSPTRP00000040201748 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQD-WEAASNNETM----ATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVL--QGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK----------TIQTMDQSD--KNSAMVNQEVLTLQEMLNS----LDFKRKEALSKMTQIIHETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLS-NRRFVLCGTNVKAMSIEESSN--GSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--GRGLNSDQLHMLAEKL--TVQSSYSDGH---LTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQ-----PCE-VSRPTERGDKGYVPSVF------IPISTIRSDSTEPHS--PSDLLPMSPSVYAVLRENLSPTTI-ETAMKSPYSAE----------------------------- stat4_ENSECAP00000021075748 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQD-WEAAANNETM----ATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVL--QGKFHGNPMHVAVVISNCLREERRILAAANMPIQGPLEKSLQSSSVSERQRNVEHKVTAIKNSVQMTEQDTKYLEDLQDEFDYRYK----------TIQPMDQGD--KNSALMNQEVLTLQEMLNS----LDFKRKEALSKMTQIVNETDLLMNNMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPMQRAHLLERVTFLIYNLFKNSFVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLS-NRRFVLCGTHVKAMSIEESSN--GSLSVEFRHLQPKEMKSSTGNKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSATLSQLLEVMSWQFSSYV--GRGLNSDQLNMLAEKL--TVQSSYSDGH---LTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYSSQ-----PCE-VSRPTERGDKGYVPSVF------IPISTIRSDSTEPQS--PSDLLPMSPSVYAVLRENLSPTTI-ETAMKSPYSAE----------------------------- stat4_ENSMMUP00000007424741 MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQD-WEAASNNETM----ATILLQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVL--QGKFHGNPMHVAVVISNCLREERRILAAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK----------TIQTMDQSD--KNSAMMNQEVLTLQEMLNS----LDFKRKEALSKMTQIIHETDLLMNNMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLEEQSTKMTYEGDPIPVQRIHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLS-NRRFVLCGTNVKAMSVEESSN--GSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--GRGLNSDQLNMLAEKL--TVQSSYSDGH---LTWAKFCKEHLPGKSFTFWTWLEAILDLIKKHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSENGEVRFHSVEPYNKGRLSALPFADILRDYKVIMAENVPENPLKYLYPDIPKDKAFGRHYSSQ-----PCE-VSRPTERGGKGYVPSVF------IPISTIRSDSMEPHS--PSDLLPMSPSVYAVLRENLSPTTI-ETAV------------------------------------ stat4_ENSXETP00000010127668 ------------------------------------------------------------------------------------VHNEKKSNSNL--KGKYHGNPMHMAMIVSNCLREERRILAAASMPIQGPFEKSLQTNLISERQRVLENKVAAIKNSAQVTEQDVKYLEDLQDEFDFRFK----------TIQSKDTTD--KHNILIEQECYKLQEMLNA----LDQKRKEALRKMSQIIDEIDTLMGKSLTEELKNWKRRQQIACIGGPLHGSLDQIQNWFTLLAESLFQLRRQIQKLDELWTKVTYEGDPIPLQKQYLLDRVICLILSVFQSSFIVERQPCMPTHPQRPLVLKTEIQFTVKLRLLV--KLPELNYQLRVKATI-----DKSILFCS-NRRFVLFGTPVKVMSIEDSAN--GSLSVEMRHLKPKESKSNSGNKGHEGVHMVTEELHSISFETQVCLYG--LAIDLETSSLPVVMISNVSQLPSAWASVIWYNLFSSEPQNHAFFANPPTASLNQLLEVLSWQFSSYV--GRGLNSEQLNMLGDKLI-GVPVNQGDNH---ISWVKFCKEHLPGKPFSFWAWIEGILELIKKYLLSIWIDGCIMGFVSKEKERALLKDKIPGTFLLRFSESHLGSITFTWVDLSDTGEVRFHSVEPYNKGRLNALPFPDILRTYKVIEAENAPENPLLYLYPDVPKDKAFGKHYNSH-----QNE-VSQPTEN-VKGYVPSVF------IPMSKLPTNGSSSPS--PMD-LPMSPSIFAALREQLTYTEI-ENDVSSSTVTF----------------------------- stat4_ENSTNIP00000021019736 MSQWKQIQQLENRLLEHVDYLYDDNFPMDVRQVLASWIESQDCLEAAEEDSSSLSTCGSELLS------DEELGNVQRGRNIYPHHDITGLPLLLCSQLKYSSSPANMAKVIATCLKEERRILSSACMQEQVCLLTRKLLLPVNQSSYNMDNRVGLIRGSVQLMDQAVKYIEDMQEDFDFRYK----------TLQSRDSTD--RNSDSMKQEVTRLQDMLNR----LDFKRKEILSKMDVAVKEIEDLMTSQLSPELQDWKRRQQ-AAIGGPLLTGLEQLQNWFTLTAQSLFQIKRQLDKLGELVIKVTYECDPIPLQKPHLEERVKYLLYHLIRSSFVVETQPCMPTHLQKPLIIKTGVQFTTKVRLLV--KLPEVDYQLKVKTTF-----DKKLKFFR-SRQFFILTNNTKVMDIEDYSN--GCLSVEFRHLQLKEKKYINGTKGNEGLLSVTEELHSLSFEACFTVQG--LTIDLETCSLPLVVISNVSQLPGGWASVMWYNLLTEEPRNLAFFCNPPRATWSQLSEVLSWQFSTLA--GQGLNREQLSMLGEKL--LGTHVWSEYH---VSWSRFAKENIPGKPFSFWMWLDSILELIRKHLQPVWTADYIMGFVSKEMERNLLKDREPGTFLLRFSESHLGGITFTWVEHKDNGEVKFNSVEPYTKNRLSALPFVDIIRDYKVISDGVVPENPLKFLYPDIPKDEAFGRLYNSQ-----RSK-GKRAEPS----PGPDPW----------DLLADSVLSPS-------PSSPPVHPYLLSTLIPISVRETASSAPASCQ----------------------------- 433424244433224323322433344322422442444243443232223223113222422223234322222222423242233232320244440322034022323432343343433224232231133331303222323232222322322334222322432332432432343333333333132322122333232222243322430343233334333434232422222232223322242244224444442423444322342344323332423334223432332322232333234332322222333223432422234334244333333324222442234323244423344332233234422233333342222224432322222223232232333334244334433324324222323333422244443332244222232333433333424442424333443322343224342232222332342343233234424323334332233344432234234234423022232242111322423433422443232442432233233444234243443234443432332443342344444444343344443343222223132323334323233433334432343133222223333332334434442343234233444442223222222222223243221333311301222022222223322202312402220323232222242222222222233333333333133333133311333333 CSSCSCSCCCSSSSCSSSSSSCSSSCCSSSCSSCCSCCCSCSCCSSSSSSSSSSSSSSSSCSSSSSSSCSSSSSSSSSCSSSCSSSSSSSSS0SCCCC0SSS0SC0SSSSSCSSSCSSCSCSSSSCSSSSSSSSSSSSS0SSSSSSSSSSSSSSSSSSSSSCSSSSSSCSSSSSCSSCSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSCSSSSCS0SCSSSSSSCSSSCSCSSSCSSSSSSSSSSSSSSSCSSCCSSCCCCCCSCSSCCCSSSSCSSCCSSSSSSCSSSSCSSSCSSSSSSSSSSSSSSSSCSSSSSSSSSSSSSSSCSSCSSSSCSSCSCCSSSSSSSSCSSSCCSSSCSSSSCCCSSSCCSSSSSSSSCCSSSSSSSSSCSSSSSSCCSSSSSSSSSSSSSSSSSSSSSSCSCCSSCCSSSSCSSCSSSSSSSSSCSSSCCCCSSSSSCCSSSSSSSSSCSSSSSCSCCCSCSCSSSCCSSSSSCSSSCSCSSSSSSSSSSSCSSCSSSSSSCCSCSSSSSCSSSSSSSCCCSSSSCSSCSSCCSS0SSSSSSCSSSSSSSCSSCSSCSSCCSSSSCCSCSSSSSSSSCCCSSCSCSCCSSSCCCSCSSSSSCCSSCSSCCCCCCCCSCSSCCCCSSCSSSSSSSSSSSSSSSCSSSSSSCSSSSCCSSSCSSSSSSSSSSSSSSSSSSCCSCCCSSCSSSCSSSCCCCCSSSSSSSSSSSSSSSSSCSSSSSSSSSSS0SSSS0SSSSSSSSSSSS0SSSSC0SSS0SSSSSSSSSSCSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS